Title: Dyadic transfer of romantic nostalgia
Authors: Jordan Stables, Krissy Le, Julie A. Swets, & Cathy Cox

Problem: Nostalgia, a sentimental longing for the past, is associated with greater psychological outcomes, with recent work showing how nostalgia for the past of one’s romantic relationship may have benefits for the self (e.g., Mallory, Spencer, Kimmes, & Pollitt, 2018; Sedikides & Wildschut, 2018). Specifically, individuals who are more nostalgic are likely to claim higher satisfaction in their romantic partnerships. However, it is not yet known whether sharing these nostalgic thoughts can benefit the other partner and the relationship. The goal of the current study is to reveal that sharing relationship-oriented nostalgia will result in beneficial well-being effects that are comparable to those created by individual nostalgia.
Method: We recruited 146 romantic couples from a local university to participate. One member of each romantic relationship was randomly assigned either to write about a nostalgic experience they shared with their partner (relationship nostalgia), a personally nostalgic experience, or a control topic. Then they answered a variety of relationship questionnaires measuring relationship outcomes (e.g., relational self-esteem, optimism). At a later date, their partner (who was blind to their partner’s involvement in the study) read their written narrative and provided their own written response to what they read. Finally they responded to the same relationship measures. Additionally, Pennebaker, Booth, Boyd, and Francis’ (2017) Linguistic Inquiry and Word Count (LIWC) was used to content analyze the nostalgic essays based on affect, sociality, time perspective, and other pertinent themes.
Results: Analyses of variance were conducted to analyze the links between essay condition, nostalgia, and well-being outcomes. First, we found that the more nostalgic the writing partner was, the more nostalgic the reading partner was. Then using LIWC, we found that the relationship nostalgia essays were generally longer, more authentic, and included more first-person plural pronouns (e.g., we, us; demonstrating a stronger sense of interdependence in the essays). It was also found that reading a relationship-centered nostalgic narrative had a significantly positive effect on the readers’ positive mood, when compared to personally nostalgic experiences or control writings. These results also varied as a function of attachment avoidance and anxiety, which is consistent with past research (Abeyta, Routledge, Roylance, Wildschut, & Sedikides, 2015; Juhl, Sand, & Routledge, 2012).
Conclusions: This study has important implications for the analysis of shared nostalgic memories. We reveal that there are clear and immediate benefits for romantic relationships of engaging in and communicating shared nostalgia. This research also is foundational for exploring correlational and causal connections between shared romantic nostalgic reverie and its individual and relationship outcomes. Specifically, future work should explore additional mediating and moderating effects of the advantages of a shared sentiment for the past, as well as the duration of these positive effects.

Children who are adopted often experience early-life trauma, resulting in dysregulation and trauma-related emotional and behavioral problems. When these children are brought into adoptive homes, these trauma-related symptoms could negatively affect the attachment relationship by adversely impacting the parent’s perspective on the parent-child relationship. The current study examined the relationship between trauma symptoms in children who were adopted and the quality of the parent-child relationship within these families. Participants included adoptive families who were participating in a therapeutic camp intervention. The data analyzed was baseline data from a larger study prior to any intervention being done. Trauma symptoms of the adopted child, including anxiety, depression, anger, and post-traumatic stress arousal, were significantly correlated with parenting communication, confidence, and frustration. Specifically, the more trauma symptoms an adopted child exhibited, the poorer the quality of the parent-child relationship. Understanding this relationship and the bidirectional effects of trauma on adopted children and adoptive parents could result in better therapeutic interventions for families with adopted children, leading to better outcomes for both adopted children and adoptive parents.

Dyslexia is a prevalent developmental disorder characterized by unexpected reading difficulty in children and adults with otherwise normal IQ and intelligence. Dyslexia is a heterogeneous disorder and a variety of deficits are observed in the population, with auditory perception and rapid stimulus processing occurring most frequently. Genetic variants are likely related to this heterogeneity. One such gene that has been reliably linked to dyslexia is the neural migration gene DCDC2. Suppression of this gene in a rat model dramatically impairs speech-sound discrimination ability from a stream of rapidly-presented auditory stimuli (Centanni et al., 2016), suggesting a potential role for this gene in rapid stimulus processing deficits in humans and supporting a prior study linking this gene to reading speed (Neef et al., 2017). One potential casualty of processing speed impairments is the ability to process unpredictable stimuli. In the current study, we designed a rapid speech sound discrimination and prediction task to evaluate whether the rapid speech sound impairment previously linked with Dcdc2 also causes deficits on a prediction task. If increased presentation rate impairs the ability to process unpredictable stimuli, then the addition of a stable predictor sound should improve performance. To test this hypothesis, homozygous Dcdc2-knockout, heterozygous, and wild type rats were trained to respond to a target sound /dad/ in a stream of rapidly presented distractors in the presence or absence of a predictor sound /bad/, which occurred reliably prior to the target in 40% of trials. In wild type rats, the results indicate the presence of a predictor enhances response to the target /dad/ at low speeds, but as the stimulus presentation rate increased the rats began responding to the predictor /bad/ rather than the target. I will present these findings as well as pilot data from rats with Dcdc2 knockout to investigate the role of this gene on the response to a stable predictor.

A recent study (Petursdottir & Oliveira, accepted pending revision) found that when comparing equivalence-based instruction (EBI) to a complete instruction (CI) control condition using concurrent training and equal mastery criteria, EBI did not inherently produce faster or better learning than CI. However, this study included only a single EBI training structure. The purpose of the present experiment was to (a) evaluate the efficiency of linear series (LS) and one-to-many (OTM) EBI protocols relative to CI, and (b) to assess transfer of function following the three arrangements. Sixty undergraduate students were assigned to one of three groups (CI, EBI-OTM and EBI-LS), all of which received training to establish three 4-member stimulus classes. In the class establishment phase (ABCD training), the CI and EI groups were presented with 36 and 9 types of trials, respectively. After achieving mastery criterion, the ABCD test included all possible trial types, with no feedback. After achieving criterion on the ABCD test, all participants proceeded to transfer of function phase, in which they were taught to execute different motor responses to one stimulus in each class, and then tested with the remaining stimuli in each class. Results suggest the OTM protocol, but not the LS protocol, was more efficient than CI. The three groups performed equally well on the transfer-of-function test.

Language learning in adulthood is often important for personal or vocational reasons, but learning a second language after the sensitive period ends is time-consuming and retention is difficult. Research has suggested that cervical vagus nerve stimulation (cVNS) can help to improve cognitive function (Sjogren et, al. 2002) and working memory in patients (Sun et al., 2017). Transcutaneous auricular vagus nerve stimulation (taVNS), a less invasive method, activates similar brain structures as cVNS (Yakunina, Kim, & Nam, 2016). Recently, our lab demonstrated that taVNS paired with training improved letter-sound learning in typically-developing young adults (Thakkar et al., under review). The current study was designed to evaluate this approach in language learning. During a training session, they were exposed to 30 words in Palau, their English translations, and a picture that corresponded to the word while receiving either active or sham stimulation to the outer left ear. Each stimulus was repeated 10 times. At the end of training, a free-recall test was given where participants saw a trained word and provided the English translation. After one week, participants completed the same free-recall test of English translations to evaluate retention of the 30 trained words. While data collection is still in progress, we are seeing trends in the hypothesized direction such that those receiving active stimulation recall more words after training and at retention than those receiving sham stimulation.

Adopted children often have trauma–related emotional and behavioral problems, such as depression, anger, and anxiety, and these problems can continue to exist after adoption. Post-adoption, the adoptive family’s impact on these problems is not well understood. The current study examines the relationship between adopted children’s trauma symptoms and family communication – a construct that is associated with child social-emotional adjustment in traditional, biological families. Data was collected from adoptive families who were recruited to participate in a therapeutic family intervention. The results revealed a significant negative correlation between family communication and trauma-related emotional and behavioral problems in adopted children; specifically, the healthier the family communicated, the less problems the adopted child exhibited. Further, we wanted to determine if a similar relationship was found between biological children’s emotional problems in adoptive families and family communication. The results revealed a similar relationship: the healthier the family communicated, the less emotional problems the biological children experienced. The results of this study indicate that family communication may be a significant factor when considering the severity of adopted children’s trauma-related emotional and behavioral problems post-adoption.

As the threat of antimicrobial-resistant infections continues to rise, the need for novel antibiotics grows. Targeting virulence factors in bacterial pathogens is one potential strategy for antibiotic development because inhibiting virulence would decrease the ability of the pathogen to evade the host immune response. This strategy may decrease the development of resistance since the treatment is not directly bactericidal and there is less selective pressure put on the bacteria population. Our goal is to discover new virulence genes in Bacillus anthracis that could potentially be a therapeutic target. Specifically, we are interested in finding genes that allow B. anthracis to acquire iron from the host. For bacterial pathogens, iron is critical for growth and often a limiting nutrient in the host. It has been linked with proper functioning of electron transfer proteins and superoxide dismutase enzymes. In B. anthracis infection, iron is acquired from host hemoglobin through a hemolytic pathway, but the complete mechanism of this is unknown. Approximately 1000 transposon mutants of B. anthracis were screened for the inability to acquire iron from hemoglobin, and five were deficient in acquiring iron from hemoglobin in in vitro assays. Of those five mutant strains, only one (9F12) also exhibited an in vivo phenotype using the wax worm model of infection. The gene disrupted in the 9F12 transposon mutant is the dUTPase/aminopeptidase gene. Our aim in this study is to confirm that the disruption of the dUTPase gene leads to the inability to acquire iron from hemoglobin in B. anthracis. Using targeted mutagenesis, we created an insertional mutant strain to disrupt the dUTPase gene and we are currently testing it, along with WT and 9F12, for the ability to grow in iron-limited conditions with or without hemoglobin. Confirmation of this phenotype will demonstrate that the dUTPASE/aminopeptidase gene is important for iron acquisition from hemoglobin and will support further studies to understand the role of this gene in the virulence of B. anthracis.

Aquatic parameters such as increased temperatures and dissolved oxygen levels is critical in determining the survival and ability to thrive of trout species, including the Bonneville cutthroat trout. Bonneville cutthroat trout (Oncorhynchus clarkia Utah), a subspecies of Yellowstone cutthroat trout, originated in the Bonneville Basin and is native to many river basins in Utah, Wyoming, Idaho, and Nevada(Duff 1996). East Canyon Creek is a headwater tributary in the Weber River Basin of northern Utah, and a stream where Bonneville cutthroat trout are native. However, due to the introduction of nonnative trout and multiple causes of habitat quality decline, they no longer occur in the stream. Over the summer of 2018, I participated in data collection which assessed the habitat qualities of East Canyon Creek. This data includes temperature, aquatic, and riparian qualities. Data on the corresponding summer for dissolved oxygen is available as well. When compared to Colorado’s Coldwater Criteria, it appears that the temperatures of East Canyon Creek exceeded the acute (22.1°C) and chronic (17.0°C) upper thermal thresholds for cutthroat trout(Todd et al 2008). When compared to the acute (5.0 mg/L) and chronic (6.0 mg/L) dissolved oxygen minimum concentrations(Null et al 2017), East Canyon Creek’s concentrations appear to have dropped below the identified concentrations. The objective of this paper is to statistically analyze the temperature and dissolved oxygen data on East Canyon Creek from 2018, and determine if a restoration project of Bonneville cutthroat trout in East Canyon Creek would be successful. Through the data analysis, we have found that water temperatures during the summer months have significantly exceeded both acute and chronic upper survival limits, and that dissolved oxygen concentrations are significantly lower than the minimum chronic survival level, indicating that East Canyon Creek is not yet suitable for a successful reintroduction of Bonneville cutthroat trout.

The BRCA1 gene encodes an 1863 amino acid protein that is relevant in many essential biological pathways, most notably DNA damage response and tumor suppression. In many instances, BRCA1's functions depend on interaction with other cellular components. One such binding partner is P53, another important tumor-suppressing protein that cooperates with BRCA1 to inhibit cancer cell growth. However, the nature of this interaction is not yet fully understood. Here we developed a biochemical assay to investigate the exact binding site for P53 in the central domain of BRCA1. The discovery of such binding sites allows future studies to identify the precise amino acid residues involved in binding and better predict the effect of mutations in the binding site on BRCA1's ability to inhibit carcinogenesis.

Breast cancer (BC) is the second most commonly diagnosed cancer among American women after skin cancer. Traditional treatments of BC include surgery, radiation, and chemotherapy therapy; however, these treatments are non-specific and potentially kill peripheral, healthy cells. There emerges a need for more specific treatments, most notably to develop chemotherapy agents that target a unique feature of the cancer cells. Interestingly, 70% of BC cells upregulate estradiol-dependent pathway, a characteristic essential for rapid cell growth. Current BC drugs, such as Herceptin and Tamoxifen, have targeted this pathway to preferentially kill BC cells. However, most women relapse within 15 years due to drug-resistance. Thus, there is a need for new chemotherapeutic drugs. Our research group studies a novel estrogen-receptor targeting drug: Est-3-Melex. This compound has the estradiol molecule linked to a DNA alkylating agent, Melex. We hypothesize that Est-3-Melex enters the cancer cells via an interaction between the estradiol moiety and the estrogen receptor alpha (ER-alpha). ER-alpha then enters the nucleus and binds to Estrogen Response Elements on the DNA. This movement positions the Melex moiety on the DNA and allows the transfer of a methyl group to the N3 adenine on the DNA. In this project, we test the hypothesized mechanism of action of our compound. Since Est-3-Melex has a DNA methylation component (Melex) conjugated to estrogen, our hypothesis is that after the drug binds to the estrogen receptor in the cytosol, it translocates to the nucleus, specifically methylates the N3-region of adenine bases, eventually triggering cell death.