Abstract: Researchers hypothesize that the initial amount of virus will affect the severity of the disease. They also believe that this will affect the amount of antivirals needed. We used mathematical modeling to study the effect of the initial viral dose on the effectiveness of antivirals. We simulated Sars-Cov-2 infections starting with different amounts of virus and treated with different amounts of antivirals, then measured the duration of the infection. This mathematical model predicts little to no effect on the amount of antivirals needed when the starting dose of virus is changed.

Title: Saving Important Material: An Examination of Offloading, Memory, and Metacognition.

Authors: Ashley J. Berdelis, Morgan D. Shumaker, Sarah K. Tauber

Cognitive offloading—externally storing information to reduce internal cognitive load (e.g., on a smartphone)—has become widespread with technological advances (Risko & Dunn, 2015). Often, offloading is used when we need to remember information in the future (e.g., setting calendar reminders). However, sometimes how much to-be-remembered material we can offload is constrained by time or by available storage space. The agenda-based regulation (ABR) framework posits that learners assess task constraints prior to study and construct agendas to achieve the task goal within these constraints (Ariel & Dunlosky, 2009; 2013). For instance, learners allocate more study time to and selectively study more important (high-value) over less important (low-value) material, allowing them to maximize test performance under such constraints (Soderstrom & McCabe, 2011; Middlebrooks & Castel, 2018). Thus, learners might adopt similar offloading strategies by offloading important material and using internal memory for unimportant material. Critically, people often engage in offloading with the expectation that their external store will be available to them at the time of need; however, this is not always the case (e.g., technology failing). When offloaded material is available at the time of need, memory for that material is enhanced (Park et al., 2022). When offloaded material is unavailable at the time of need, memory for offloaded material suffers compared to memory for internally stored (recalled) material (Park et al., 2022). To use external tools most effectively, it may be useful for learners to be aware of their ability to remember externally and internally stored material. Thus, the current study examined whether learners are aware of their ability to later remember offloaded and internally stored material. Participants completed a series of memory tasks with the option to offload only a portion of the to-be-remembered items. Before the study phase in each task, participants made judgments about how much of the offloaded and recalled items they could later identify as having been seen before. After the study phase, participants made similar post-task judgements and were given a surprise recognition test on the studied material, during which the external store was unavailable.
We also examined whether learners could transfer their metacognitive awareness from one task to another, as offloading is relevant to various life scenarios. Finally, we examined how the value of the to-be-remembered material influences offloading, and how offloading and recall influence later memory. Participants’ pre-task judgements on the first task indicated that they would recognize more offloaded items than recalled items. However, this difference was not present on tasks two and three, suggesting that participants used experience with the first task to update their judgments for offloaded items. Participants offloaded more high-value than low-value items and had better recognition memory for recalled items than offloaded items, in all three tasks. Overall, people strategically offload important over unimportant material, but memory for offloaded material suffers compared to memory for recalled material. Learning about the relationships between value, offloading, memory, and metacognition can allow us to use external storage devices more effectively.

The introduction of the birth control pill allowed women to express greater control over their fertility. Since then, men have had less responsibility when it comes to family planning, as the majority of birth control technologies have been directed toward women, thereby creating an implicit association between femininity and the use of birth control. Currently, male birth control is in various stages of research, and when one becomes available, this association may decrease men’s willingness to use this contraceptive. Indeed, previous research has shown that men’s lower willingness to use a male birth control is associated with a desire to avoid appearing feminine. Therefore, increasing the association between masculinity and birth control could increase men’s willingness and interest in using a male birth control. The present study aimed to examine whether the degree to which a male birth control is associated with masculinity in an advertisement (ad) will influence men’s willingness to, and interest in, using the birth control. I predicted that the stronger the ad associated male birth control with masculinity, the more that men would be willing to/have an interest in using the depicted birth control. Participants viewed one of two ads for a male birth control, either a masculine ad or a non-masculine ad, and then indicated their willingness and interest in using the depicted birth control. We also measured men’s self-reported openness to short-term, uncommitted sexual relationships. Results suggested that similar willingness and interest in using the birth control was reported between the masculine ad and the non-masculine ad, suggesting that men’s willingness/interest was not influenced by the masculinity of the ad. However, the results did reveal a moderating effect of men’s sexually unrestricted desires. More specifically, when men viewed the non-masculine ad, there was no association between men’s willingness to use the depicted male birth control and their desires for short term, uncommitted sex. However, among the men who viewed the masculine ad, the more they desired short-term, uncommitted sexual relationships, the more willing they were to use the advertised birth control. Overall, these findings suggest when men are motivated to pursue short-term, uncommitted sex, they are then more willing to use a male birth control if that birth control is associated with masculinity. The implications of these findings for research on family planning will be discussed.

Retrieval practice typically improves learning and memory performance of basic information (Rowland, 2014). Much less research has evaluated the degree to which retrieval practice results in better test performance of more complex information such as category learning. In one case, retrieval practice led to superior classification performance relative to restudy conditions (Jacoby et al., 2013); however, in another, it did not (Babineau et al., in press). One important component that may contribute to retrieval practice effects in category learning is whether the learning process is self-regulated. We systematically explored this issue with the goal to establish when retrieval practice benefits learning of complex categorical information. During the experiment, we manipulated the study strategy (Retrieval practice versus Study) and the learning context (Experimenter-controlled versus Self-regulated) between-participants during a complex category learning task. Specifically, participants learned to classify six categories of organic chemistry compounds. For participants in the retrieval practice groups, participants practiced classifying each exemplar into the correct category and received corrective feedback after each trial. Participants in the study groups did not complete practice test trials. Instead, they studied all exemplars without practicing category classification nor did they get feedback on their learning. For participants in the experimenter-controlled groups, the order of the trials was fixed in an interleaved order. However, participants in the self-regulated groups made decisions about what to study after each trial. They were able to study a compound of the same type, a compound of a different type, or proceed to the test (after viewing 72 exemplars. After the study phase concluded, participants completed two classification tests. During the novel classification test, participants classified new exemplars they had never seen from the six chemical categories they just studied. During the studied exemplar test, participants classified the exemplars they had previously studied. The results revealed that participants who completed retrieval practice trials during the study phase performed better on the novel and studied classification tests than did participants who completed study trials. The benefit of practice testing on complex category learning was maintained for participants who self-regulated their learning and for participants whose learning was experimenter-controlled. The results of the present research support the use of retrieval practice as an effective study strategy for complex categorical information. Further, retrieval practice improved classification performance for those who self-regulated their category learning. Students often self-regulate their learning of complex information, and these novel findings indicate that completing a practice test improves student learning in controlled environments like the classroom, as well as in student-controlled environments such as studying outside of the classroom.

Frustration is a complex emotional state that occurs when reward expectations are violated. In animals, this can involve a variety of different types of rewards such as food, shelter, or access to mates. When an animal learns to expect a certain reward and that reward is of lesser quality or quantity than expected, the animal will reject the reward and experience a bout of negative emotion known as frustration. This behavior is often modeled in the lab in a paradigm known as consummatory successive negative contrast (cSNC) and involves training rats to expect a high value sucrose solution (32%) and then downshifting them to a lower value sucrose solution (2%). As a result of this downshift, consummatory behavior is shown to be suppressed beyond that of unshifted controls. To better understand the brain circuitry behind this response, neural activity of several key brain areas was assessed after a 32-2% sucrose downshift with additional 32-32% and 2-2% controls using immunohistochemistry. More specifically, the protein c-Fos, which is expressed in recently depolarized neurons and can therefore act as a proxy for neural activity, was quantified in brain areas relating to reward processing, emotion regulation, and action coordination. The results show several areas that are activated and correlate with one another during downshift. These data provide the groundwork for establishing a connectome of brain areas that are activated during cSNC and are essential to frustration.