Bridging the Gap in PrEP Uptake: A Literature Review on HIV Prevention Among Black Women and Community-Rooted Strategies

Type: Undergraduate
Author(s): Anne Shubert Psychology Pamela Carey Psychology Savannah Hastings Psychology Kevin Knight Psychology Randi Proffitt Psychology Stephanie Villaire Psychology
Advisor(s): Randi Proffitt Psychology Kevin Knight Psychology
Location: Third Floor, Table 1, Position 3, 1:45-3:45

Women remain disproportionately affected by human immunodeficiency virus (HIV), with disparities in acquisition risk research concentrated among Black women in the Southern United States. Although there are effective prevention tools such as Pre-Exposure Prophylaxis (PrEP), uptake of these tools remain low. This review analyzes the critical gap in prevention and protection against HIV in Black women. Systemic search of PubMed (2010-2025) was conducted looking for keywords such as “Women and PrEP”, “Barber Shop Model”, “Beauty Shop Model”, “Mobile Health Unit Health Care”, “PrEP Education”, and “Birth Control”. Reducing HIV disparities among Black women requires changing structural and social factors that influence the high HIV risk-factors. Awareness and self-perceived risk must be considered at the individual level in order to effectively prevent HIV acquisition. Existing research shows that the way prevention services are delivered and designed affect the efficacy of HIV prevention efforts. In addition to advancing biomedical strategies, interventions should be culturally responsive to increase awareness and reduce stigma surrounding PrEP and HIV. Overall, HIV disparities among Black women are multifactorial, and shifting prevention efforts into trusted community spaces while addressing the structural roots of medical mistrust shows a promising strategy for narrowing the gap in HIV prevention.

The Link Between Natural Mentoring and Resiliency in the Face of Adverse Experiences and Insecure Attachment

Type: Undergraduate
Author(s): Jessie Swartz Psychology Lillyan Shelley Psychology
Advisor(s): Danica Knight Psychology
Location: SecondFloor, Table 9, Position 2, 11:30-1:30

Resilience is the ability to cope with and overcome difficulties. Childhood traumatic events can undermine resilience by disrupting emotion regulation, coping skills, social connectedness, and self-esteem, thereby reducing an individual's ability to cope effectively. A commonly used metric for assessing these events is Adverse Childhood Experiences (ACEs), which examines exposure to abuse, neglect, and household dysfunction. One way to increase resilience is through a secure attachment to a caregiver. However, if an individual lacks a secure attachment to their caregiver, supportive relationships, such as natural mentors (NM; kin, non-kin, helping professionals), can also foster resilience. The present study examines whether having a NM is associated with higher resilience, while accounting for adverse experiences and insecure attachment to primary caregivers. Approximately 300 TCU students will be recruited to complete an online survey assessing ACEs, resilience, attachment to their caregiver, and any prior relationship with a NM. Descriptive analyses, one-way ANOVA, two-way ANOVA, and stepwise multiple regression will be conducted to examine associations. Descriptive analyses will examine the prevalence of all variables. Individuals with different types of NM mentors are expected to report different levels of resilience. Additionally, individuals with a NM are expected to demonstrate greater resilience when accounting for ACEs. Finally, the presence of NMs is expected to be associated with greater resilience compared to individuals without a mentor, even after controlling for insecure attachment. Data collection will begin in March 2026 and continue throughout the month, with results and implications being presented at the conference.

Birth control, cycle phase, and inflammatory response to an immunological stimulus

Type: Undergraduate
Author(s): Emma Tawadrous Psychology Alexandra Hock Psychology
Advisor(s): Sarah Hill Psychology
Location: SecondFloor, Table 5, Position 1, 1:45-3:45

Cytokines are a protein involved in the body’s inflammatory response to pathogen threats (Danzter, 2001), and there is evidence that long-term oral contraceptive use can increase generalized inflammation (Mongiovi et al., 2025). Sickness symptoms are related to higher cytokine levels (Dantzer & Kelley, 2007), and further research found that participants who experienced more sick effects (injection-site soreness, fatigue, muscle aches, etc.) post-flu shot showed higher cytokine levels than those with less intense sick effects (Christian et al., 2015). We wanted to know if there is a difference in post-flu shot cytokines levels and sick symptoms between naturally cycling women vs. women on hormonal birth control (HBC)/ We also wanted to know if there is a relationship between phase of menstrual cycle and levels of inflammation after a flu shot. To answer these questions, we recruited 47 women from the TCU flu-clinic. The morning after their flu shot, participants gave a blood-spot samples (stored on Whatman 903 protein saver cards), completed a survey on their HBC use, menstrual cycle phase, GRIT, mood and feelings, and sick symptoms. The data are currently undergoing multi-variate analysis, where birth control use (naturally cycling vs. HBC use) and menstrual cycle phase are the predictor variables, and cytokine levels, sick symptoms, GRIT, and mood and feelings are the dependent variables. Blood spot samples will be analyzed in May 2026 using Mesoscale Discovery V-Plex assay kits. We expect to find a relationship between HBC use and cytokine levels, and sick symptoms and cytokine levels. We also expect to find a relationship between HBC use and GRIT, mood and feelings, and sick symptoms. We do not have any expected outcomes for the relationship between menstrual cycle phase, cytokines levels, and sick symptoms, as this research is exploratory.

Meaning in Life and Time Perception: The Moderating Effects of Obsessive Compulsive Tendencies

Type: Undergraduate
Author(s): Roselyn Tentzohua Psychology
Advisor(s): Cathy Cox Psychology Bao Han Tran Psychology
Location: Basement, Table 7, Position 2, 11:30-1:30

People with obsessive-compulsive disorder (OCD) tendencies experience intrusive, uncontrollable thoughts and images that elevate anxiety. These tendencies could potentially influence time perception, which is the subjective experience of time passage. Time scarcity is the feeling that you don’t have enough time to complete tasks. In contrast, time affluence is the feeling that you have more than adequate time to complete tasks. Research has shown that time affluence is positively associated with meaning in life, while time scarcity has a negative association with meaning of life. This study examines how OCD tendencies influence the relationship between time perception and meaning in life. Participants (N = 360) were recruited from Prolific and were randomly assigned into 1 of 3 conditions (i.e., time scarcity, time affluence, vs. control). Following the completion of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) to measure OCD traits, participants underwent a manipulation by reading a vignette that primed them about the tightness or openness of time in a work environment. After the manipulation, participants completed the Meaning in Life Questionnaire. This research will guide future work on how time-scarce or time-affluent environments affect OCD symptomology.

The Impact of Stigmatizing Language on Social Distance and Treatment Support for Individuals with Substance Use Disorder

Type: Undergraduate
Author(s): Muskaan Toor Psychology Amritleen Brar Psychology Lily Cantrell Psychology Isabella Dias Psychology Elayna Hodge Psychology Kate Leininger Psychology Brianna Pitz Psychology Michelle Puebla Psychology Jiya Sharma Psychology
Advisor(s): Amanda Sease Psychology Kevin Knight Psychology
Location: Basement, Table 6, Position 3, 11:30-1:30

Stigma is a pervasive issue in society, with stigmatizing language describing individuals with substance use disorder (SUD) negatively impacting coping effectiveness, treatment-seeking, and interpersonal relationships (Luoma et al., 2008). Previous research has found that labeling individuals with SUD is associated with public fear and desire for minimal social contact (Link et al., 1999). Additionally, stigmatization of this population has been associated with reduced support for public health policy and greater support for punitive policies (Kennedy-Hendricks et al., 2017). The current study examined whether the language used to describe an individual with SUD affects perceptions of social distance and support for treatment. Community members in Tarrant County were approached in public areas and invited to participate in a survey regarding individuals with SUD. Participants were randomly assigned to read one of two different vignettes written in either person-first language or stigmatizing language, then completed survey questions via tablet or QR code. We hypothesize that participants reading stigmatized language will report greater desired social distance from the individual with SUD and display less support for treatment engagement. These findings would suggest that efforts to reduce stigmatizing language in public discourse, such as media campaigns, healthcare training, and policy reform, are critical to fostering more supportive attitudes toward treatment and recovery for individuals with SUD.

Disgust, Inflammation, and Effort: Investigating the Immune System's Role in Motivation and Decision-Making

Type: Undergraduate
Author(s): Emma Wilner Psychology Talia Chachkes Psychology
Advisor(s): Sarah Hill Psychology
Location: Third Floor, Table 4, Position 1, 11:30-1:30

Throughout history, pathogens have posed a major threat to human survival. In response, humans have developed both physiological and behavioral defense mechanisms, including the immune system, which helps combat infections. Disgust serves as a crucial defense, preparing the body for exposure to potential pathogens before they enter the body. Since internal state changes redirect energy toward immune activity and healing, inflammatory responses may also influence willingness to exert effort in various contexts. This study examines how disgust affects effort exertion for rewards or to avoid costs. We hypothesize that disgust increases inflammation, which in turn reduces willingness to exert effort. We propose that this shift is driven by energy conservation due to an inflammatory response, rather than a reduced desire for rewards or avoidance of costs. Participants will be exposed to disgust-inducing stimuli while inflammatory markers (core body temperature, heart rate, and blood cytokines) are measured. Their willingness to exert effort for rewards or to avoid costs will also be assessed. Findings may offer insights into adaptive decision-making, clarifying how an immune response triggered by disgust impacts motivation and effort allocation. 

Inducing a State of Surrender: Effects on Predictors of Panic Disorder Symptoms

Type: Undergraduate
Author(s): Michael Wrucke Psychology
Advisor(s): Cathy Cox Psychology Thomas Sease Psychology
Location: SecondFloor, Table 4, Position 3, 11:30-1:30

Anxiety sensitivity (AS) refers to the fear of bodily sensations typically associated with physiological arousal. High AS is a transdiagnostic predictor of poor mental health outcomes, such as panic disorder, other anxiety disorders, post-traumatic stress disorder, and overall functional impairment. Individuals with high AS may exhibit body hypervigilance, and in turn, be more likely to experience psychosomatic symptoms. A State of Surrender (SoS) refers to one's ability to accept what is to come without resistance and relinquish control. It has been associated with greater well-being, and preliminary data suggests it is negatively associated to anxiety and AS, mediated by distress tolerance. To further test this, we will recruit individuals on Prolific and randomly assign them to either a surrender-based meditation protocol or a control condition. We will measure functional somatic symptoms, trait anxiety, distress tolerance, self-efficacy, and anxiety sensitivity. We predict that individuals in the experimental condition will endorse less AS, mediated by self-reported SoS. We also predict that the effect will be greater for individuals with more somatic symptoms. Findings will suggest further exploration of acceptance-based treatment for individuals with high AS and other psychosomatic complaints.

Family Dysfunction, Youth Emotion Dysregulation, and Caregiver Strain Among Families of Youth Involved in the Legal System (YLS)

Type: Undergraduate
Author(s): Hampton Zidlicky Psychology
Advisor(s): Danica Knight Psychology
Location: SecondFloor, Table 8, Position 3, 11:30-1:30

Youth involved with the juvenile justice system are disproportionately exposed to trauma, family stressors, and environmental obstacles. Although family dysfunction, emotion dysregulation, and caregiver strain have been studied in relation to youth delinquency, there’s a gap in the research examining the interaction between these three factors among families with youth involved in the juvenile justice system. Shaped by Bowen’s Family Systems Theory and Social Learning Theory, this study explored triangular associations among emotion dysregulation, family dysfunction, and caregiver strain.
Baseline data were drawn from the parent study, Leveraging Safe Adults (LeSA), which drew 220 youth and their caregivers from nine juvenile detention centers across Texas and Illinois. Among other measures, the youth completed the Difficulties in Emotion Regulation Scale (DERS) and the Youth Family Assessment Device (Y-FAD), while the caregivers completed the Caregiver FAD (C-FAD) and the Caregiver Strain Questionnaire-Short Form (CGSQ-SF). Analyses examined correlations among the three factors.
Results indicated a moderate, statistically significant positive correlation between C-FAD and CSQ, but no significant relationship between Y-FAD and CSQ. The relationship between CSQ and DERS was small, but not statistically significant. Both Y-FAD and C-FAD were related to higher DERS reports.
By analyzing emotion dysregulation, family dysfunction, and caregiver strain reciprocally and interdependently rather than in isolation, this study helps to provide a better understanding of the objective socioemotional processes of and between youth and their families involved in the juvenile justice system. It also highlights the importance of incorporating both youth and caregiver perspectives into study design and assessments.

Effects of Parental Diet on the Offspring's Epigenome and Expression of Genes Associated With Alzheimer's Disease

Type: Undergraduate
Author(s): Nicholas Boehly Biology Bridey Brown Biology Emersyn Jorski Biology
Advisor(s): Dr Matthew Hale Biology
Location: SecondFloor, Table 9, Position 1, 1:45-3:45

Nick Boehly, Bridey Brown, Emersyn Jorski, Matthew Hale

Texas Christian University, Department of Biology

Previous studies have shown that nutrition plays a key role in influencing epigenetic markers. Additionally, changes in gene expression have been linked to the development of Alzheimer’s disease (AD). However, it is unclear how, and to what effect, nutrition influences changes in the epigenome. To that end, we divided mice into groups and exposed them to two different diets 1) a typical American diet (TAD) and 2) a Mediterranean diet (MD). Although it is known that diet can induce epigenetic modification, it is unknown if these changes are heritable. There has been little research that has focused on the offspring of the mice fed with these diets. Therefore, this experiment will focus on how the diets of parental mice affect their offspring’s methylation patterns of previously identified candidate genes linked to the development of AD. Prefrontal cortex samples from F1 mice, whose parents were exposed to MD or TAD, were removed, and the RNA was extracted and reverse transcribed into cDNA. This cDNA will display levels of expression by 10 distinct genes that have been linked to AD in previous studies. Our goal is to identify correlations between nutrition and the development of AD through modifications of gene expression. Moreover, this data will help illustrate how inheritance of epigenetic modifications can influence gene expression in subsequent generations.

Investigation of the Presence and Impact of Heavy Metals in the Trinity River

Type: Undergraduate
Author(s): Drew Carlton Biology Dalton Allen Biology Marlo Jeffries Biology Katie Solomons Biology Reagan Spickard Biology
Advisor(s): Marlo Jeffries Biology
Location: Basement, Table 15, Position 2, 1:45-3:45

The Trinity River is an important body of water to the state of Texas as it is a source of drinking water for the Dallas-Fort Worth and Houston Metropolitan areas, a popular location for recreational activities, and an ecologically significant habitat for a variety of organisms. Due to its urban location, the Trinity River is subject to potential heavy metal pollution from wastewater treatment plant discharge, road runoff, and industrial activities. Heavy metal exposure has been shown to cause significant adverse impacts on aquatic organisms; thus, this project aimed to evaluate the presence and biological impact of heavy metals in sediment and surface water samples collected from the Trinity River. Water samples collected from the Trinity River were tested for the presence of heavy metals using ICP-OES. Larval fathead minnows were also exposed to sediment and surface water samples collected from the Trinity River and gene expression levels of five biomarkers were measured. Metallothionein was used as a biomarker of exposure to heavy metals, catalase and superoxide dismutase were used as biomarkers of oxidative stress, and heat shock proteins 70 and 90 were used as biomarkers of generalized stress. The results of this study provide insight into the extent of heavy metal contamination in the Trinity River, as well as its potential impact on aquatic life.

Efficacy of Repurposed ClpXP Protease Inhibitors in Bacillus anthracis Sterne Strain

Type: Undergraduate
Author(s): Braden Chadwick Biology Alex Caron Biology Sheridan O'Coyne Biology Katherine Richey Biology Mikaela Stewart Biology
Advisor(s): Shauna McGillivray Biology
Location: Basement, Table 15, Position 1, 11:30-1:30

As increasing antimicrobial resistance continues to limit treatment options for bacterial infections, several new approaches have sought to avoid the challenges faced by traditional antibiotics. One such approach is targeting virulence factors, which are necessary for pathogens to evade host defenses and establish infection but not for survival outside the host. This strategy could provide an effective form of treatment while reducing selective pressures for bacteria to evolve resistance mechanisms. Studies have shown that the ClpXP proteolytic complex is essential for virulence in Bacillus anthracis and that deletion of the ClpX subunit increases sensitivity to the cell-envelope-targeting antibiotics penicillin and daptomycin as well as the human antimicrobial peptide LL-37. Previously, we used computational modeling to identify commercially available inhibitors of the ClpXP complex and demonstrated that one, ritanserin, mimics the phenotype of a B. anthracis ΔclpX knockout mutant in antimicrobial susceptibility assays. In this study, we evaluated ritanserin in comparison to four other inhibitors identified during the same screen—siramesine, xaliproden, fluspirilene, and R59022—by determining the fractional inhibitory concentration (FIC) index of each when used in combination with penicillin. Notably, all inhibitors used except R59022 have undergone at least phase II clinical trials for other purposes. We found that two out of the three inhibitors with the highest predicted binding affinity, ritanserin and siramesine, exhibited synergistic interaction with penicillin, while the remainder of the interactions were indifferent. Our results further demonstrate the potential of structural biology techniques to identify and repurpose existing drugs for use as novel antibiotics.

Type: Undergraduate
Author(s): Nia Chambers Biology
Advisor(s): Giri Akkaraju Biology
Location: SecondFloor, Table 8, Position 1, 11:30-1:30

Chronic inflammation is a major contributor to neurological damage in diseases such as Alzheimer’s, which currently affects nearly 7 million Americans. The NF-kB signaling pathway plays a critical role in mediating inflammatory responses, as it regulates the expression of several pro-inflammatory cytokines, such as TNF-alpha, that exacerbate neuroinflammation. This study investigates the effectiveness of novel compounds in regulating TNF-alpha induced NFkB activation, using a luciferase reporter assay.

Expanding the Potential for Bacteriophage Therapy: Isolation of Phages against ESKAPE Pathogens

Type: Undergraduate
Author(s): Sophie Cronk Biology Cassidy Hunter Biology Katherine Lesslie Lesslie Biology Aeron Pennington Biology
Advisor(s): Shauna McGillivray Biology
Location: Third Floor, Table 5, Position 1, 11:30-1:30

Expanding the Potential for Bacteriophage Therapy: Isolation of Phages against ESKAPE Pathogens

Sophie Cronk, Katherine Lesslie, Cassidy Hunter, Aeron Pennington, Shauna M McGillivray

Bacteriophages are viruses that selectively infect bacteria and propagate to overtake the host species.

They are also being developed as a treatment for otherwise drug-resistant infections. Though

bacteriophage therapy has not been FDA approved; it has been used in cases of compassionate care.

Because of the success in these cases, bacteriophage is offering a promising alternative to antibiotics

in the fight against antibiotic resistance. One issue in mainstream bacteriophage use is them

selectivity. Phages infect a specific bacterial species or a particular strain within the species.

Therefore, multiple phages may be required in a ‘phage cocktail’ to ensure there is a phage infects a

target bacterial strain. The goal of our bacteriophage study was to gather data about

where phages are heavily populated and to refine protocols to ensure optimal bacteriophage

collection. Bacteriophage that attacks different bacterial hosts tends to be found in locations

that commonly accumulates that specific host bacteria. A secondary goal is to isolate as many phages as

possible against bacterial species known as the ESKAPE pathogens. The ESKAPE pathogens are Staphylococcus aureus, Enterobacter

aerogenes, Pseudomonas aeruginosa and Klebsiella pneumoniae. These are clinically relevant

because their antibiotic resistance poses a threat to public health due to their ability to cause severe

infections. We have successfully isolated bacteriophage for Pseudomonas aeruginosa, Klebsiella,

and Enterobacter and we are actively exploring different environments for phage that will infect

S. aureus.

Investigating the effects of patient variants and phosphorylation on the BRCA1/PALB2 interaction

Type: Undergraduate
Author(s): Audrey Dolt Biology Chrissy Baker Biology Precious Castillo Biology Hayes Martin Biology Jamison Speed Biology Mikaela Stewart Biology
Advisor(s): Mikaela Stewart Biology
Location: Basement, Table 11, Position 1, 11:30-1:30

BRCA1 and PALB2 proteins suppress tumor formation by promoting homologous recombination when DNA damage has occurred. Mutations in BRCA1 and PALB2 are associated with a higher prevalence of breast and ovarian cancers. It is established that phosphorylation of BRCA1 and PALB2 occurs in or near the coiled-coil region of both proteins. This domain is utilized by both proteins to heterodimerize, so we hypothesize that phosphorylation events could affect BRCA1/PALB2 interaction affinity. We are using Isothermal Titration Calorimetry and Circular Dichroism to determine if phosphorylation affects the structure or function of minimized binding domains from BRCA1 and PALB2. We will present our findings from the PALB2 phosphorylation sites which, contrary to our hypothesis, do not affect binding to BRCA1, as well as forthcoming data on the BRCA1 phosphorylation sites. In addition, we are using the minimized constructs and similar techniques to study questions regarding the effect of variants of unknown significance on the structure and function of these regions. While we have many variants remaining to test, thus far we find that the coiled-coil structure is destabilized by the introduction of proline variants in particular; therefore these variants disrupt the binding between PALB2 and BRCA1 and are more likely to be detrimental. We will present a summary of the variants tested to date and our working hypothesis regarding structure and function disruptions in the coiled-coil domains of BRCA1 and PALB2.

The impact of novel Alzheimer’s Disease therapeutics on the activation of the pro-inflammatory transcription factor NF-ⲕB

Type: Undergraduate
Author(s): Lal Durmaz Biology
Advisor(s): Giridhar Akkaraju Biology
Location: Third Floor, Table 3, Position 3, 1:45-3:45

Inflammation is a natural and beneficial response to injury and pathogen invasion. However, chronic inflammation is linked to the progression of various neurodegenerative diseases. Although the exact etiology is unknown, Alzheimer’s disease is associated with the overactivation of the NF-kB inflammatory pathway. NF-kB is a transcription factor that, in an unstimulated cell, is sequestered in the cytoplasm as a complex with its inhibitor, IκBα. When the pathway is activated by an external signal, IκBα is phosphorylated and subsequently degraded in the proteasome. Liberated NF-κB translocates to the nucleus, where it acts as a transcription factor for pro-inflammatory genes, highlighting its potential as a therapeutic target. Our research investigates the exact point of interference of novel anti-inflammatory drugs (provided by P2D Biosciences) with the NF-kB pathway through Western blotting and immunofluorescence.

Characterizing a C. elegans Model for Oxidative Stress Response

Type: Undergraduate
Author(s): Nicholas Findlater Biology Madelynn Farhat Biology
Advisor(s): Thushara Galbadage Interdisciplinary Giridhar Akkaraju Biology
Location: SecondFloor, Table 9, Position 1, 11:30-1:30

Neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease are characterized by progressive neuronal loss, often driven by oxidative stress. The accumulation of reactive oxygen species (ROS) contributes to cellular damage, making oxidative stress a key factor in disease pathology. Caenorhabditis elegans, a genetically tractable model with conserved stress response pathways and neuronal structures, provides an effective system for studying oxidative stress and neurodegeneration. This study aims to establish an optimized oxidative stress assay in C. elegans to evaluate protective effects against ROS-induced damage. Wild-type (N2) C. elegans were synchronized via a bleaching protocol to generate a uniform population of young adults. Lifespan and survival assays were performed using tert-butyl hydroperoxide (tBHP) to induce oxidative stress, testing concentrations of 10, 1, 0.1, and 0.01 mM. Higher concentrations (10 and 1 mM) resulted in rapid mortality of C. elegans within 3 and 9 hours, respectively, whereas lower concentrations (0.1 and 0.01 mM) allowed survival beyond 12 hours. Based on these findings, an optimal tBHP concentration will be used to further refine this oxidative stress model. This study provides foundational data for investigating the efficacy of potential antioxidant molecules in reducing ROS-related damage. By using the C. elegans model, future research will focus on identifying molecular mechanisms of oxidative stress response and evaluating therapeutic candidates for neurodegenerative diseases.

Genetic Variation in Alligator Weed Influences Herbicide Effectiveness Across Regions

Type: Undergraduate
Author(s): Namandeep Gill Biology Dean Williams Biology
Advisor(s): Dean Williams Biology
Location: Basement, Table 2, Position 3, 11:30-1:30

Alligator weed (Alternanthera philoxeroides) is a highly invasive species that threatens waterways, agriculture, and ecosystems worldwide. While herbicide treatments have successfully managed populations in Mississippi, they have been less effective in Australia and New Zealand. This research investigated whether genetic differences among populations contribute to these inconsistencies in control effectiveness. To test this, we genotyped alligator weed samples from Mississippi, Australia, and New Zealand using chloroplast DNA markers to identify haplotypes. Results revealed significant genetic variation among regions. Mississippi populations exhibited greater haplotype diversity, with Ap1 and Ap3 being dominant, whereas Australia and New Zealand were primarily composed of Ap2, Ap3, and Ap5. The genetic lineages used in Mississippi herbicide trials did not directly match those found in Australia and New Zealand, suggesting that differences in herbicide response may be linked to genetic variation. These findings indicate that current herbicide trials may not accurately predict effectiveness in non-U.S. regions. Future testing on genetically relevant populations will improve control strategies, ensuring more effective management of alligator weed globally.

EmpowerHer STEM Club

Type: Undergraduate
Author(s): Lilli Gonzales Biology Hermela Leul Nutritional Sciences
Advisor(s): Christina Ayala Biology
Location: SecondFloor, Table 1, Position 1, 1:45-3:45

EmpowerHer STEM Club is an after-school program dedicated to encouraging young girls to explore careers in science, technology, engineering, and mathematics (STEM). In collaboration with E.M. Daggett Elementary School, the program seeks to address the gender gap in STEM fields, where women currently hold only 28% of STEM occupations. Research suggests that early mentorship plays a crucial role in shaping young women's academic and career aspirations.
EmpowerHer STEM Club provides mentorship and hands-on learning experiences to inspire and support young girls in their STEM interests. The program introduces students to diverse STEM fields through interactive experiments that complement their classroom curriculum. Additionally, participants learn about various STEM careers and the achievements of influential women in these fields. Through this engaging approach, EmpowerHer STEM Club fosters curiosity, confidence, and a passion for STEM while building connections with the next generation of leaders.

The Effects of Novel Anti-Inflammatory Drugs on LPS-Induced Cytokine Gene Expression in BV2 Cells

Type: Undergraduate
Author(s): Ana Herget Biology Giridhar Akkaraju Biology
Advisor(s): Giridhar Akkaraju Biology
Location: Basement, Table 7, Position 3, 1:45-3:45

Alzheimer’s Disease (AD), the most common form of dementia, currently impacts almost seven million people in the United States over the age of 65. It is predicted that by 2060 over 13 million people in the United States will be affected by AD, which is why there is a growing demand for treatments. Amyloid ꞵ plaques and phosphorylated tau proteins are both associated with the progression of the AD pathology since they play a role in the disruption of neuronal integrity. These aggregated proteins along with other molecules, such as lipopolysaccharide (LPS), lead to increased inflammation by activating the NFκB pathway. The NFκB pathway controls the production of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNFɑ); however, if it is overactive, it can lead to harmful inflammation.The company P2D Biosciences provides novel compounds designed to reduce inflammation, but the exact mode of action of these compounds is unknown. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) can be utilized to measure cytokine mRNA from BV2 cells that have been pretreated with the drugs and then with LPS. In this project we screened multiple compounds provided by P2D Biosciences to evaluate their use as anti-inflammatory agents to treat AD.

Investigating the ubiquitin ligase activity of BRCA1 from C. elegans

Type: Undergraduate
Author(s): Lauren Herrington Biology
Advisor(s): Mikaela Stewart Biology
Location: Third Floor, Table 8, Position 1, 1:45-3:45

BRCA1 is a tumor suppressor protein that normally acts with its partner, BARD1, to facilitate DNA repair, regulation of the cell cycle, and regulation of gene expression. The Caenorhabditis elegans homologs of BRCA1 and BARD1, BRC-1 and BRD-1, respectively, retain these key functions and thus make C. elegans a suitable model organism for studying the functions of BRCA1. While the functions of BRCA1 and BRC-1 are well characterized, the molecular mechanisms by which these functions are carried out is still unclear. For example, BRCA1 and BRC-1 possess E3 ubiquitin ligase activity towards histone H2A in nucleosomes, but it is unknown how this contributes to tumor suppression. While inherited mutations that disrupt tumor suppression lack E3 ligase activity, they also interfere with other critical molecular functions, such as BARD1 binding. To pinpoint the role of E3 ligase activity, we aim to characterize a mutant construct of BRC-1 in C. elegans that lacks E3 ubiquitin ligase activity towards histone H2A but retains the ability to bind BRD-1. In vitro ubiquitination assays demonstrate that our candidate for this mutant of BRC-1, Trip A, is ligase-dead towards histone H2A in nucleosomes. Co-purification of BRC-1 and BRD-1 in which only BRC-1 contained the histidine tag revealed that BRC-1:BRD-1 binding is retained in the Trip A mutant. While these results demonstrate that Trip A meets in vitro requirements for a ligase-dead mutant, further in vivo experiments are needed to confirm its suitability. If confirmed as a suitable ligase-dead mutant through in vivo experiments, Trip A can be expressed in C. elegans to identify which functions of BRC-1 depend on E3 ubiquitin ligase activity towards histone H2A in nucleosomes.

Identifying the nucleosome ubiquitylation role of BRCA1 in transcriptional regulation using C. elegans

Type: Undergraduate
Author(s): Elizabeth Hoff Biology
Advisor(s): Mikaela Stewart Biology
Location: FirstFloor, Table 1, Position 1, 1:45-3:45

BRCA1 is a tumor suppressor protein that facilitates DNA damage repair, cell cycle checkpoints, and gene expression in humans. The presence of pathogenic mutations in the BRCA1 protein leads to a predisposition to breast and ovarian cancers in humans; these pathogenic mutations can lead to the dysregulation of enzymatic activity and gene expression. It is hypothesized that enzymatic activity of BRCA1 and its ability to regulate gene expression are linked. The gene expression of estrogen-metabolism genes by BRCA1 is mediated, in-part, by the ability of BRCA1 to facilitate the mono-ubiquitylation of nucleosomes on the H2A histone. Our lab is interested in understanding which DNA damage repair and gene expression functions of BRCA1 rely on mononucleosome ubiquitylation. In Caenorhabditis elegans, the BRCA1 homolog, BRC-1, retains the key functions of BRCA1, making C. elegans a suitable model organism to evaluate which functions of BRCA1 rely on nucleosome ubiquitylation. To explore nucleosome ubiquitylation by BRC-1 in C. elegans, we compare three strains of C. elegans, including a wildtype strain, a complete knockout of BRC-1, and an engineered mutant. This engineered mutant contains two point mutations that alter the ability of BRC-1 to interact with the nucleosome to complete ubiquitylation of the H2A histone. We suggest that our proposed mutant repels BRC-1 from the histone to prevent ubiquitylation, yet retains all other BRC-1 functions. We hypothesize that this will hinder the repression of cyp genes, which code for enzymes that catalyze the process that converts estrogen into various metabolites, some of which are harmful. Overexpression of these genes can lead to the accumulation of harmful estrogen metabolites, which can lead to tumorigenesis in estrogen-metabolizing tissues. To assess this, we compare the expression levels of cyp genes, which are repressed in the wildtype strain containing a functional copy of BRC-1. If mononucleosome ubiquitylation is required for transcriptional repression in C. elegans, in the engineered mutant strain, we expect to see elevated levels of cyp gene expression, as also seen in the complete BRC-1 knockout strain. Through understanding the mono-ubiquitylation of nucleosomes by BRC-1 in C. elegans, we can better interpret the genetic variations of BRCA1 in humans and better inform and treat patients with detrimental BRCA1 mutations.

Trade-offs between environmental concerns and disease control influence disease dynamics across communities

Type: Undergraduate
Author(s): Redon Limani Biology Kenny Lai Biology Grant Xiong Biology
Advisor(s): Jing Jiao Biology
Location: Third Floor, Table 6, Position 2, 11:30-1:30

Mosquitoes are primary vectors in the transmission of many infectious diseases, spreading pathogens through their bites after feeding on infected
hosts. Vector-borne diseases like Zika, chikungunya, and yellow fever, mostly transmitted by mosquitoes, cause over 700,000 deaths each year and
account for 17% of infectious diseases, heavily burdening vulnerable communities and economies. Public perception of mosquito control can significantly shape outbreak outcomes [1]. This project uses a mathematical model to simulate how disease spreads between two regions connected by mosquito migration. The model considers how people’s concern for the environment can influence their support or opposition to mosquito control efforts. Our goal is to explore how these factors shape disease prevalence and to better understand the role of community behavior in outbreak prevention.

New Smiles Drive

Type: Undergraduate
Author(s): Alexandra Much Biology Aimee Garibay Interdisciplinary Annie Loomis Biology Sarina Schwarze Biology Kameryn Smudde Nutritional Sciences
Advisor(s): Sarah Jung Biology
Location: SecondFloor, Table 8, Position 2, 11:30-1:30

Oral health is a critical component of overall well-being, yet many individuals in underserved communities lack access to essential dental care and hygiene resources. The New Smiles Drive is a student-led initiative dedicated to improving oral health education and access to hygiene supplies in the Fort Worth community. Through the TCU Tooth Fairies program, we present at elementary schools, engaging students in interactive lessons on proper brushing and flossing techniques to foster lifelong oral hygiene habits. Additionally, we donate hygiene kits—containing toothbrushes, toothpaste, floss, and a laminated educational card outlining proper brushing steps in both English and Spanish—to Mercy Clinic, which provides medical and dental care to uninsured patients, as well as to local homeless shelters. By combining education with tangible resources, New Smiles Drive aims to promote preventive dental care and address disparities in oral health access.

In Vitro Evaluation between 5-LO Inhibitor, Zileuton, and Antifungal Activity Against Cryptococcus

Type: Undergraduate
Author(s): Khoi Nguyen Biology Natalia Castro Lopez Biology Floyd Wormley Biology
Advisor(s): Natalia Castro Lopez Biology Floyd Wormley Biology

Total Mercury (THg) Levels in Tricolored Bats (Pipistrellus subflavus) in East Central Texas

Type: Undergraduate
Author(s): David Peebles Biology Cami Middlebrooks Biology Benjamin Strang Biology
Advisor(s): Matt Chumchal Biology
Location: SecondFloor, Table 3, Position 3, 11:30-1:30

Mercury (Hg) is a trace element metal with toxic effects on wildlife, including bats. Texas is the largest producer of mercury pollution in the United States, yet only 2 other studies have measured the concentration of mercury in bats. We measured total mercury concentrations (THg) in fur (n=57) in the endangered species Tricolored bats (Pipistrellus subflavus) collected from two culverts in Fresstone County in East Central Texas. Fur THg concentrations were compared between sex, culverts, and previous studies in the U.S.. There was no significant difference in THg between sex or culvert, but there was a significant difference with the Tricolored bats in the Northeastern U.S.. However, the THg values were not significantly different from those of previous studies conducted in Texas. Additionally, the THg concentrations were compared with the 10 ug/g toxicity threshold levels commonly used, with 5.2% of Tricolored bats in this study exceeding this toxicity threshold. This suggests that THg may pose a risk to the health of bats in East Central Texas, and protective measures need to be implemented to protect this species.