Geochemistry of Ediacaran-Ordovician diabase, lamprophyre and phonolite dikes in southern Colorado, possibly related to rifting in the Southern Oklahoma Aulacogen

Type: Graduate
Author(s): Caleb Perkey Geological Sciences Richard Hanson Geological Sciences
Advisor(s): Richard Hanson Geological Sciences
Location: Basement, Table 6, Position 1, 1:45-3:45

The Southern Oklahoma aulacogen is a northwest-trending structure containing abundant igneous rocks representing the remains of a major Cambrian rift zone. Previous geologists have mapped numerous igneous intrusions in Colorado that follow the same trend, ranging from Ediacaran to Ordovician in age, and have speculated that these intrusions may be a part of the same rift. These intrusions include abundant igneous dikes of various compositions that originated from deeper magmatic bodies, filling fracture systems in older igneous rocks and Precambrian gneisses. This study involves the geochemical analysis of samples we collected from different dike types, including diabase, lamprophyre, phonolite, and nepheline syenite. The dikes include a prominent diabase dike swarm in the Gunnison area as well as abundant dikes of several types in the Wet Mountains and Front Range farther east. On the discrimination and REE diagrams, fifteen representative dike samples from both sample regions plot tightly together, indicating the clustered dikes share a petrogenetic history of E-MORB-type magma that interacted with intercontinental lithosphere.
We have not yet found diabase dikes in the Wet Mountains suitable for geochemical studies. However, five samples from NW- to NNW-trending diabase dikes in the Front Range, ~80 km north of the Wet Mountains, are among the fifteen diabase samples that cluster together on the geochemical diagrams. This raises the intriguing possibility that dikes related to Ediacaran-Ordovician intraplate magmatism in Colorado may be more extensive than previously thought.
Samples of four lamprophyre dikes in the Wet Mountains exhibit uniform patterns in REE diagrams and plot within the same field on the Winchester and Floyd (1977) classification diagram. Three dikes classified as trachytes by other workers cluster plot in the phonolite field on this diagram, suggesting some of these dikes were previously misclassified. These three dikes also show similar REE patterns with prominent negative anomalies, implying prolonged fractional crystallization.

Nutrition Support for Sepsis Induced Acute Kidney Injury in a Critical Care Setting: A Case Report

Type: Graduate
Author(s): Blayke Anderson Nutritional Sciences
Advisor(s): Ashley Mullins Nutritional Sciences
Location: Basement, Table 10, Position 1, 1:45-3:45

Sepsis-induced acute kidney injury (S-AKI) is a critical illness that causes decreased kidney function due to infection. With a prevalence of 40-50% of patients in the intensive care unit developing S-AKI, the illness is strongly associated with a higher risk of mortality, longer hospital stays, and increased risk of kidney failure relapse. S-AKI complicates medical nutrition therapy due to altered protein metabolism, increased metabolic demands, fluid imbalances, increased malnutrition risk, and electrolyte imbalances. Goals of nutrition care include close monitoring and evaluation of fluid, meeting estimated protein needs, maintaining electrolyte and vitamin status, and achieving supplemental nutrition tolerance to optimize kidney recovery and prevent malnutrition. Various nutrition interventions, such as individualized protein needs and enteral nutrition (EN), play a role in managing this illness. Evidence-based guidelines for protein recommendations vary based on the type of renal replacement therapy (RRT) and range from 1.2-2.5 g/kg/day. Patients with declining renal function prior to RRT and at risk for chronic kidney disease have a range of 0.8-1.0 g/kg/day to preserve long-term kidney function. Literature indicates initiation of EN within 24 hours is preferred over parenteral nutrition (PN) if oral intake is not feasible to prevent malnutrition. While there are no standardized fluid intake guidelines for S-AKI, continuous multidisciplinary assessment and adjustment to fluid intake are necessary to prevent volume overload. This case report reviews the importance of proactive individualized nutrition interventions to aid in patient recovery including improved nutritional status and AKI resolution.

Impact of Next-Generation Synbiotic Supplementation on Body Weight and Metabolic Biomarkers in Individuals with Overweight or Obesity Post Antibiotics

Type: Graduate
Author(s): Melissa Fernandez Alonso Nutritional Sciences Genevieve Aiwonegbe Interdisciplinary Angela Berry Interdisciplinary Ashlyn Dooley Interdisciplinary Anne George Interdisciplinary Katie Harnen Nutritional Sciences Brooke Hodnick Interdisciplinary Jaidyn Hooper Nutritional Sciences Olivia Landis Nutritional Sciences Matthew Loritz Nutritional Sciences Sarah McKinley-Barnard Interdisciplinary Jessica Mrosla Nutritional Sciences Ryan Porter Interdisciplinary Timothy Ritter Interdisciplinary
Advisor(s): Elisa Marroquin Nutritional Sciences
Location: Third Floor, Table 4, Position 3, 11:30-1:30

Background: Research in animals and humans indicate that the gut microbiome plays a significant role in modulating insulin resistance1,2, while animal studies have demonstrated the gut microbiome's direct involvement in regulating body weight3,4. Furthermore, antibiotic use may impair insulin sensitivity and glucose tolerance in individuals with overweight and obesity5-9. However, no studies to date have evaluated the potential factors influencing this metabolic response.

Methods: This is a randomized clinical trial with a within- and between-subjects comparison. Seventy-five individuals aged 18-50 years (BMI 25.0-40.0 kg/m2), with no Diabetes Mellitus diagnosis, and no recent probiotic or antibiotic intake (3 months) were recruited. Participants were allocated to a synbiotic or placebo group for 12 weeks following a 3-day Vancomycin antibiotic intervention (500 mg every 8 hours). Body weight and fasting blood samples (glucose, insulin, HbA1c) were taken at the first (baseline), second (after antibiotic administration), and third visit (after synbiotic/placebo intervention). HOMA-IR was calculated from fasting insulin and glucose levels. Due to lack of normal distribution of independent variables, Mann-Whitney U tests were performed to evaluate within- and between-group changes over time.

Results: Compiled results for all participants were analyzed, although only 60 completed the study. It is important to highlight that the placebo group was significantly heavier at baseline (91.8 ± 18.1 kg) than the synbiotic group (82.8 ± 14.3 kg) (p=0.046), while the latter had a modest weight gain over time (~0.80 kg, p=.056). Neither fasting glucose nor HbA1C changed significantly between groups over time. HbA1c, insulin, and HOMA-IR slightly increased from baseline in all participants (p<.001 each), which could indicate a decreased insulin sensitivity over time, with no significant differences between groups.

Conclusion: Our unadjusted analysis demonstrates that providing a 12-week next-generation synbiotic supplementation posterior to a 3-day antibiotic intervention did not correct the commonly observed detrimental effect of antibiotics on insulin resistance. Furthermore, it seemed to lead to significant weight gain (~0.80 kg, p=.056).

Implications for future research: We are planning on re-running all our statistical analyses controlling for baseline sex and we are also planning on running an independent third group with synbiotic only for comparison purposes.

Funding Source: Pendulum® and TCU Dean’s Opportunity Grant

References
1. Sergeev IN, Aljutaily T, Walton G, Huarte E. Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity. Nutrients. Jan 15 2020;12(1)doi:10.3390/nu12010222
2. Wu Z, Zhang B, Chen F, et al. Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: A randomized, controlled, prospective study. Front Cell Infect Microbiol. 2022;12:1089991. doi:10.3389/fcimb.2022.1089991
3. Ridaura VK, Faith JJ, Rey FE, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. Sep 6 2013;341(6150):1241214. doi:10.1126/science.1241214
4. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. Dec 21 2006;444(7122):1027-31. doi:10.1038/nature05414
5. Del Fiol FS, Balcão VM, Barberato-Fillho S, Lopes LC, Bergamaschi CC. Obesity: A New Adverse Effect of Antibiotics? Front Pharmacol. 2018;9:1408. doi:10.3389/fphar.2018.01408
6. Klancic T, Laforest-Lapointe I, Wong J, et al. Concurrent Prebiotic Intake Reverses Insulin Resistance Induced by Early-Life Pulsed Antibiotic in Rats. Biomedicines. Jan 12 2021;9(1)doi:10.3390/biomedicines9010066
7. Park SJ, Park YJ, Chang J, et al. Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans. Sci Rep. Nov 4 2021;11(1):21681. doi:10.1038/s41598-021-01125-5
8. Yuan J, Hu YJ, Zheng J, et al. Long-term use of antibiotics and risk of type 2 diabetes in women: a prospective cohort study. Int J Epidemiol. Oct 1 2020;49(5):1572-1581. doi:10.1093/ije/dyaa122
9. Zhou J, Lin Y, Liu Y, Chen K. Antibiotic exposure and risk of type 2 diabetes mellitus: a systematic review and meta-analysis. Environ Sci Pollut Res Int. Dec 2021;28(46):65052-65061. doi:10.1007/s11356-021-16781-3

Nutrition Interventions for a Malnourished Patient with a Non-Healing Surgical Incision and History of Bariatric Surgery: A Case Report

Type: Graduate
Author(s): Isabell Franzia Nutritional Sciences
Advisor(s): Ashley Mullins Nutritional Sciences
Location: SecondFloor, Table 4, Position 2, 11:30-1:30

Medical nutrition therapy is necessary for individuals at risk of impaired wound healing, such as those with malnutrition, poor circulation, or advanced age. During the acute inflammatory response from wounds, the body enters a catabolic state, increasing energy and protein needs. For those with malnutrition or at risk for malnutrition, calories should be provided at 30-35 kcal/kg body weight and protein at 1.25-1.5 g/kg body weight. Along with increased energy needs, the assessment and management of vitamins and minerals such as vitamins A, vitamin C, vitamin K, and zinc enhance the synthesis of fibroblasts needed for tissue formation. Early diagnosis and intervention for malnourished patients with chronic wounds are critical steps in providing effective patient care. Oral intake is monitored to ensure calorie and protein intake is adequate and oral nutrition supplements may be provided if indicated. For those unable to tolerate oral feeds, enteral nutrition is the next preferred method. If enteral nutrition is contraindicated then parenteral nutrition can be initiated to provide adequate calories and protein. This case report analyzes the care of a 74-year-old female with a non-healing surgical wound with a history of bariatric surgery who has been diagnosed with malnutrition.

The Risk of Essential Fatty Acid Deficiency on Parenteral Nutrition in Long-Term Hospital Stay: Case Report

Type: Graduate
Author(s): Olivia Gasvoda Nutritional Sciences
Advisor(s): Ashley Mullins Nutritional Sciences
Location: Basement, Table 14, Position 2, 11:30-1:30

Essential fatty acid deficiency (EFAD) is a condition that can occur when the body does not have adequate fats from the diet. EFAD can develop in as quick as 10 days and can present with symptoms such as itchy and flaky skin, poor wound healing, elevated liver function tests, and increased susceptibility to infection. EFAD rarely occurs in individuals who eat a balanced diet with a variety of foods and fat sources and is seen most often in patients unable to eat by mouth or tolerate tube feedings. Patients with prolonged poor nutrition are at increased risk of EFAD due to insufficient fat intake. Risk factors of EFAD are inflammatory bowel disease, pancreatic insufficiency, extreme diet restriction, and long-term parenteral nutrition support with limited fat emulsion supplementation. Preventing EFAD through awareness and proactive measures is essential in medical nutrition therapy. Since clinical markers are challenging to assess in the acute care setting, physical signs and symptoms are used for identifying and treating EFAD. For patients on parenteral nutrition support with no fat, supplementing with 500 mL intralipids per week is recommended to prevent EFAD. This case report reviews the current nutritional guidelines related to EFAD and parenteral nutrition and highlights a patient at risk for EFAD due to her poor intake, who was receiving long-term parenteral nutrition with supplemental oral intake.

Nutritional Management of Necrotizing Pancreatitis: A Case Report

Type: Graduate
Author(s): Josephine Miller Nutritional Sciences
Advisor(s): Ashley Mullins Nutritional Sciences
Location: Basement, Table 7, Position 2, 11:30-1:30

Necrotizing pancreatitis is a severe acute inflammation of the pancreas that disrupts the release of pancreatic enzymes necessary for digestion and the production of insulin needed to stabilize blood glucose levels. Common complications associated with necrotizing pancreatitis include diet intolerance, abdominal pain, nausea, vomiting, decreased oral intake, and hyperglycemia. If the patient cannot meet their estimated nutritional requirements via an oral diet, supplemental nutrition support, such as enteral nutrition (EN) through a feeding tube or parenteral nutrition intravenously through a peripheral or central line, must be considered to prevent malnutrition. When necessary, early initiation of supplemental nutrition support within 24-48 hours of admission is associated with shorter hospital stays. To improve diet tolerance and reduce symptoms while utilizing EN, patients with necrotizing pancreatitis may be fed elemental or semi-elemental formulas through a feeding tube placed in a post-pyloric position. Additionally, insulin therapy may be utilized in cases where patients experience hyperglycemia due to exocrine pancreatic insufficiency. The target blood glucose range for hospitalized patients is less than 180 mg/dL, or less than 140 mg/dL if there is no significant risk of hypoglycemia. Insulin therapy should be initiated when a patient experiences a blood glucose level greater than or equal to 180 mg/dL at least twice within a 24-hour period. This case report evaluates the management of EN intolerance and hyperglycemia when treating individuals with necrotizing pancreatitis.

Navigating Nutrition and Complex Goals of Care in a Patient with Decompensated Cirrhosis: Case Report

Type: Graduate
Author(s): Wallace Ann Whatley Nutritional Sciences
Advisor(s): Ashley Mullins Nutritional Sciences
Location: FirstFloor, Table 2, Position 1, 1:45-3:45

Decompensated alcoholic cirrhosis is failure of the liver due to alcohol use, accompanied by complications such as portal hypertension, bleeding varices, ascites, and encephalopathy. Nutrition is vital in managing cirrhosis as the loss of hepatocytes from liver damage impairs gluconeogenesis, causing the body to use amino acids and fatty acids for energy, thereby increasing resting energy expenditure. Malnutrition is often diagnosed in patients with decompensated cirrhosis due to increased nutrition needs and comorbidities like altered mental status and ascites, which cause early satiety and negatively affect oral intake. Therefore, nutrition interventions to treat or prevent malnutrition are essential. Evidence indicates cirrhotic patients are at risk for malnutrition should eat three to five meals plus snacks to shorten fasting periods. If calorie and protein needs cannot be met through oral intake, initiating enteral nutrition may be appropriate. Enteral nutrition is preferred unless it is contraindicated, in which case parenteral nutrition would be utilized. Nocturnal enteral feeds may be permissible to shorten fasting periods if oral intake is tolerated but intake does not meet nutritional needs. Nutrient recommendation ranges for cirrhotic patients are 35 calories per kilogram and 1-2 grams of protein per kilogram, based on actual or estimated body weight. Vitamin and mineral supplementation may be needed for patients with a history of alcohol abuse, specifically thiamin, niacin, folate, magnesium, and zinc. This case report explores the complex nutrition needs and goals of care in a patient with decompensated alcoholic cirrhosis and severe chronic protein-calorie malnutrition.

Studying the Influence of Structural Differences between GaOOH Microparticles on their Antibacterial Efficiency.

Type: Graduate
Author(s): John Brannon Physics & Astronomy Pavan Ahluwalia Physics & Astronomy Arabella Blom Physics & Astronomy Louise Hutchison Biology Dustin Johnson Physics & Astronomy Sriman Reddi Physics & Astronomy
Advisor(s): Yuri Strzhemechny Physics & Astronomy Shauna McGillivray Biology
Location: Basement, Table 4, Position 1, 11:30-1:30

Ga2O3, an ultrawide-bandgap semiconducting material, sees widespread use in optoelectronic, pharmaceutical, and other industrial applications. Additionally, as antibiotic resistance grows, interest rises in the antibacterial properties of Ga2O3 and other gallium-containing compounds. In many cases, GaOOH is a precursor to synthesis of Ga2O3 with similar physiochemical properties. For microparticles, surface effects become heavily amplified. In particular, the surface effects may significantly influence antibacterial action. We synthesize GaOOH and Ga2O3 microparticles via hydrothermal growth. We employ scanning electron microscopy to image samples and energy dispersive X-ray spectroscopy to characterize the stoichiometry. X-ray diffraction spectroscopy is used by us to monitor bulk structural differences between the GaOOH precursor and Ga2O3. To monitor crystal defects we utilize photoluminescence spectroscopy. For antibacterial assays, we test our materials against Staphylococcus aureus bacteria using optical density measurement at 600 nm.

Quantifying Spatial Heterogeneity of Syncytial Cells using Alpha Shapes

Type: Graduate
Author(s): Anthony Gerg Physics & Astronomy
Advisor(s): Hana Dobrovolny Physics & Astronomy
Location: FirstFloor, Table 6, Position 2, 1:45-3:45

We introduce a structural method used for quantifying the spatial heterogeneity(or clumpiness) of viral syncytial cells in a transfection bioassay. The solution lies in an inter-disciplinary process based on simplicial topology being applied to a biological system. Our method revolves around using topological theories including Delaunay tessellations and Voronoi graphs to signify cell-cell interaction probability. The main emphasis is the subset of Delaunay tessellation called Alpha shapes. By applying a filtration to the overall Delaunay tessellation, we can obtain unique Alpha Shapes that have cell-cell interactions removed. The emphasis of the filtration is to find the correct shape where there were no connection crossing syncytia, only between healthy neighborhoods of cells. The process allows for the associated alpha number to be assigned to the clumpiness. Alpha numbers can then be used to separate different bioassays, or quantify temporal changes found in a single viral transfection due to syncytia.

Analyzing a Mathematical Model for Virus Propagation of the Trachea

Type: Graduate
Author(s): Geoffrey Hennessy Physics & Astronomy
Advisor(s): Hana Drobrovolny Physics & Astronomy
Location: FirstFloor, Table 4, Position 1, 1:45-3:45

The lining of the human respiratory tract (HRT) has a layer of ciliated cells known as an epithelium. When exposed to virus, these cells actively push virus into mucous layers lining the epithelium and then funnel this mucous up and out of the human respiratory tract. This process is called mucociliary clearance (MCC) and is the first line of defense against a viral infection. We know that MCC plays a role in preventing respiratory infections, but we know little else. We hypothesize that, under the right conditions, MCC prevents infection by limiting the ability for virus to enter the lower respiratory tract. To test this, we constructed a compartmental model that uses a system of diffusion-driven partial differential equations to describe the virus propagation in the HRT as a travelling wave front with an advection term included to approximate MCC.  Our model shows that MCC can change the waveform of the virus propagation, and suggests that there exists a critical advection speed that prevents virus from entering the lower respiratory tract.

Inflows or Outflows: Tracing the Path of Gaseous Arms in the LMC

Type: Graduate
Author(s): April Horton Physics & Astronomy Suraj Poudel Physics & Astronomy
Advisor(s): Kat Barger Physics & Astronomy
Location: Third Floor, Table 6, Position 1, 1:45-3:45

Our neighboring galaxies, the Large Magellanic Cloud (LMC) and Small Magellanic Cloud (SMC), interact with each other as they move through the hot, outer region of the Milky Way. This interaction can pull and sweep away gas from the edges of the galaxies, forming large, stretched-out clouds of gas. The LMC has two gas filaments that resemble arms, which connect to a region where stars are formed, possibly hinting toward their origin or their final destination. In this study, we used radio observations and data from the Hubble Space Telescope to search for signs of these gas arms near the star-forming region. We find a continuous stream of gas that could be the arms located at least partially in front of the LMC. The positioning of these arms raises two competing questions: 1) Is the gas flow fueling new star formation in the LMC, or 2) Is gas from exploded stars in the LMC flowing out into these arms? While the inflow of gas makes sense for these gas flows, we also conducted simulations of outflows from the starburst region. Our results suggest that it is possible for debris from exploded stars to be swept into the arms. Future observations will help us better reconstruct the arms’ evolutionary history.

Star Clusters in the Milky Way: What are They and How Do We Use Them?

Type: Graduate
Author(s): Jonah Otto Physics & Astronomy Natalie Myers Physics & Astronomy
Advisor(s): Peter Frinchaboy Physics & Astronomy
Location: Basement, Table 5, Position 2, 11:30-1:30

Star clusters are incredibly useful tools in the pursuit of understanding our Universe better. They can be used to discover how our Galaxy, the Milky Way, formed and evolved over time, delve into the secrets of how stars form and even track how the different chemistry around our Galaxy. However, determining whether a group of stars is truly a star cluster or just a group of stars is a difficult task. In this poster, we will go over what a star cluster is, how we determine membership of the star cluster and the current work we are doing to investigate galactic chemical abundance gradients using star clusters.

Turning Up the Heat on Cancer: Photothermal-Triggered Chemotherapy Delivery with Graphene Quantum Dots

Type: Graduate
Author(s): Ugur Topkiran Physics & Astronomy Ibrahim Bozkurt Computer Science
Advisor(s): Anton Naumov Physics & Astronomy
Location: FirstFloor, Table 6, Position 1, 1:45-3:45

Cancer remains a major global health challenge, with over 20 million new cases diagnosed annually. Conventional treatments like chemotherapy, while effective, often require high doses due to non-specific targeting, leading to severe side effects. To overcome these limitations, we developed a targeted drug delivery platform using graphene quantum dots (GQDs), which offer high biocompatibility, near-infrared (NIR) fluorescence, and photothermal properties. In this study, hyaluronic acid-conjugated GQDs HA-GQDs and RGQDs, synthesized top down from reduced graphene oxide, are loaded with doxorubicin, paclitaxel, and gemcitabine, were tested in vitro using a custom-built, fully automated system for NIR laser irradiation and real-time spectral monitoring. Drug release was triggered by GQD-mediated photothermal heating and evaluated via MTT assays and fluorescence tracking. This work presents a novel, cost-effective nanocarbon-based drug delivery system integrating targeted therapy and photothermal control for enhanced cancer treatment.

Introductory Notes as Motor Preparatory Motor Gestures Underlying Zebra Finch Song

Type: Graduate
Author(s): Soseh Asadoorian Psychology Kevin Bien Psychology Andrew Magee Psychology Dimitri McLain Psychology Samantha Shah Chemistry & Biochemistry Emily Sugg Psychology
Advisor(s): Brenton Cooper Psychology
Location: Basement, Table 4, Position 3, 11:30-1:30

Humans produce complex and learned behaviors like speech, playing musical instruments, and sports through exceptional motor abilities. These learned actions need specific motor planning and preparation. Researchers use songbirds in part because they produce a stereotyped motor sequence whenever they engage in singing behavior. Further, Zebra Finches learn their song through vocal production learning, similar to human speech acquisition; they mimic their adult male tutor's song and reproduce a similar version in adulthood. This motor learning process leads to the generation and execution of a highly skilled and stereotyped motor program production. Before the song, Zebra finches sing a sequence of introductory notes that are short-duration, non-stereotyped sounds. Previous work has speculated that these introductory notes are a form of motor preparation, but an experimental test of this hypothesis has not been conducted. This study casually examines the role of introductory notes as a motor preparation phase to help transition to executing the main song motor sequence. To distinguish motor preparation from song execution, we reasoned that presenting an external stimulus would delay preparation but not execution. We used air pressure recording to identify introductory notes and triggered white-noise playback during the introductory note performance in six birds and found that the external stimulus led to a delay, which can lead to interruption of the typical song motor pattern (e.g., abnormal pauses). Whereas the same stimulus presented during the song either caused an abnormal early termination of the motor program or did not affect the song (continuation), but it did not delay the execution of the song's motor gestures. Our findings suggest that introductory notes are flexible and modifiable by external stimuli, which is consistent with the hypothesis that they function as a preparatory motor gesture for the upcoming stereotyped song.
Understanding motor planning can provide insight into neurological, behavioral, speech, and motor disorders that are characterized by deficits in neuromuscular preparation.

I Think Your House is Haunted: Associations Between Adverse Childhood Experiences (ACEs) and Existential Isolation

Type: Graduate
Author(s): Tiffany Bui Psychology Kayla Rabb Psychology
Advisor(s): Cathy Cox Psychology
Location: Basement, Table 8, Position 1, 11:30-1:30

Existential isolation can be described as the experience of feeling alone in one’s experience of the world; that no one shares your experience or comes close to understanding it (Pinel et al., 2017). Research on existential isolation remains novel, however current findings among those chronically existentially isolated has found significant associations with a host of negative affective outcomes, including increased loneliness (Pinel et al., 2017), death thought accessibility (Helm et al., 2019), depression and anxiety (Constantino et al., 2019), and reduced self-esteem and self-worth (Helm et al., 2018). Finally, there is novel and consistent evidence that existential isolation is related to insecure attachment, specifically avoidant attachment (Helm et al., 2020).

Recent literature has found that adverse early life experiences are one of the factors that can proactively influence adult well-being, resulting in consequences such as anxiety and depressive disorders, and suicidal ideation (Hays-Grudo and Morris, 2020). Additional work has also shown that childhood abuse was uniquely associated with greater loneliness among young adults (Landry et al., 2022) but the impact of early life experiences on loneliness can be impacted by a multitude of factors including, but not limited to, age, gender, socioeconomic factors, and epigenetic factors (Southwick et al., 2014). While loneliness is inherently a part of the feeling of existentially isolated, existential isolation itself is distinct in theoretically meaningful ways that this study aims to investigate through the lenses of adverse childhood experiences and childhood uncertainty. This present study aims to qualitatively examine the relationship between adverse childhood experiences and existential isolation among adult individuals. Our findings across two studies established a positive association between individuals who have experienced adverse childhood experiences and existential isolation.

Redefining Success: What Formerly Incarcerated Individuals Value in Life

Type: Graduate
Author(s): Renee castillo Psychology Kevin Knight Psychology Thomas Sease Psychology
Advisor(s): Thomas Sease Psychology
Location: SecondFloor, Table 7, Position 2, 1:45-3:45

A Six-Factor Model of Ethical Decision-Making

Type: Graduate
Author(s): Kevin Diegel Psychology
Advisor(s): Timothy Barth Psychology
Location: Third Floor, Table 3, Position 1, 11:30-1:30

This study examines the integration of Care ethics as a distinct factor into the Ethical Perspectives Scale (EPS; Diegel et al., 2024). In contrast to typical ethical theories centering on consequentialist, deontological, and virtue ethics reasoning, Care ethics prioritizes relational and situationally appropriate moral judgment. In the conduct of four experimental studies, we made Care an independent factor by utilizing Exploratory and Confirmatory Factor Analyses, assessed its predictive validity regarding moral dilemmas, tested its temporal stability, and generalized the findings to a population outside of the student group.

Results confirmed that Care ethics is conceptually and statistically distinct from Virtue ethics, predicting moral judgments in relational and compassion-based contexts. Care ethics correlated with political ideology, religiosity, and subjective well-being, further differentiating it from other ethical dimensions. However, ethical decision-making remained highly context-dependent, with different perspectives becoming salient across dilemma types.

The findings of this research promote the integration of Care ethics into models of moral decision-making, thus highlighting its relevance to practical uses. Future studies should examine its applicability in various cultures and its impact on professional ethics training.

Impact of food insecurity on anxiety-like behavior and spatial memory in old-age C57BL/6J mice

Type: Graduate
Author(s): Logun Gunderson Psychology Morgan Bertrand Biology Gabriella Dover Biology Faith Harms-Zacharias Psychology Katie Robb Psychology
Advisor(s): Gary Boehm Psychology Michael Chumley Biology
Location: Third Floor, Table 8, Position 2, 1:45-3:45

Food insecurity affects more than 6 million households with children in the U.S., the majority of which are insecure without hunger. Food insecurity and the accompanying chronic unpredictability are associated with significant negative health outcomes, such as impaired immune function, anxiety/eating disorders, malnutrition, and delayed language acquisition. To explore the connection between the unpredictability of a food source and cognitive impairments, prior studies have attempted to model food insecurity in rodent models. An ideal study design to answer this question would expose mice to a truly unpredictable food source for an extended period and assess their behavior for any significant changes, but most of the prior work has not been able to make a truly unpredictable food source which limits the generalizability of their findings. To address these limitations, the present study aimed to ensure that the rodent's food source was truly unpredictable by randomly assigning periods of limited food access across each week of the study. 18-month-old male and female C57BL/6J mice were either given ad libitum food access or were food insecure, where their otherwise full food-hopper would be reduced to 25% of their baseline consumption two randomly selected nights each week until the following morning. At 21 months, the mice underwent a battery of behavioral tests, including the open field test, elevated-zero maze, and novel object location task, to assess anxiety-like behavior and spatial memory capabilities. While insecurely-fed male mice were trending towards displaying more anxiety-like behavior than their securely-fed counterparts, we found no significant impact of food insecurity on anxiety-like behavior or spatial memory capabilities. Taken together, this study provides a more complete analysis of the behavioral changes due to a truly unpredictable food source, which more closely represents the environment of those living with food insecurity, and highlights areas to improve the model for future investigations.

Histological analysis of peripheral tissues following Typical American (TAD) or Mediterranean (MD) diet consumption in C57BL/6J mice.

Type: Graduate
Author(s): Faith Harms-Zacharias Psychology Skye Duncan Biology Sara Gabriel Biology Ashish Rana Psychology
Advisor(s): Gary Boehm Psychology Michael Chumley Biology
Location: SecondFloor, Table 5, Position 1, 11:30-1:30

At least 6.9 million Americans aged 65 and above are living with Alzheimer’s disease (AD) as of 2024, and that number is only expected to increase as the aging population grows. The exact cause of AD has yet to be discovered, but there are several significant risk factors such as sleep deprivation, a lack of exercise, and diet quality. Our lab has investigated diet quality in relation to AD pathology through the creation of two representative diets, the Typical American Diet (TAD) and the Mediterranean Diet (MD). These diets are calorically matched and are used to investigate their long- and short-term effects on Alzheimer’s pathology in C57BL/6J mice. To follow up on a previous study that used 6 months of diet exposure to explore the longer-term effects of these diets, groups of mice were fed either the TAD or MD for 3 months, beginning at 4 months of age, to better understand the short-term effects. This project then conducted histological analysis on the colon, liver, and gonadal white adipose tissue using different histological techniques. Specifically, a cryostat and microtome were used to prepare the tissue samples, and they were stained using Hematoxylin and eosin (H&E) staining and Oil Red O. Samples were then examined using confocal microscopy, and tissues from each diet were compared and analysed. We found that 3 months of diet led to excess hepatic lipid deposition, as was found in the 6-month study. Additionally, the 6-month study suggested that the TAD may have induced an insulin resistance (IR) state, so gonadal white adipose tissue was examined to explore adipocyte expansion after 3 months on diet. Preliminary colon histology was conducted to begin the exploration into gut dysbiosis and inflammation and the connection to Alzheimer’s pathology. This study presents novel histological evidence of the impact of diet quality on peripheral tissue in relation to Alzheimer’s disease.

Increasing Access to PrEP for Women of Color by Leveraging Beauty Shops as Community Health Hubs with Women's Healthcare Delivery: The Beauty Shop Study

Type: Graduate
Author(s): Savannah Hastings Psychology Pam Carey Psychology Sarah Gonzalez Psychology McKynzie Johnson Psychology Randi Proffitt Psychology Stephanie Villaire Psychology
Advisor(s): Kevin Knight Psychology
Location: Basement, Table 8, Position 2, 1:45-3:45

Each year, Black women are disproportionately affected by new HIV diagnoses. Recent data of HIV cases in Texas indicate that approximately 56% of new HIV cases in women occur in Black women, despite them making up only 13% of the female population in the state. This stark disparity highlights the need for targeted interventions that address the barriers to accessing sexual health resources, including HIV prevention services. The Beauty Shop Study seeks to address these gaps by leveraging beauty professionals as trusted community health advocates (CHAs). These CHAs facilitate sexual health conversations and connect clients with essential healthcare services. This study evaluates the effectiveness of the two combined interventions: (a) using beauty shops as community health hubs and (b) providing healthcare through either a mobile health unit (MHU) or a referral coordinator. Participants engage in three visits with a research assistant across 6 months, which include interviews and specimen collection. In Tarrant County, participants have access to a MHU for 3 months, while in Dallas County, participants receive support from referral coordinators for the same duration. Recruitment for the present study presented several challenges, including the ineffectiveness of virtual training for CHAs and the inability to accept snowball referrals. However, outreach efforts strengthened trust, ultimately increasing referrals and community engagement. Moving forward, insights from this pilot study will inform the development of future iterations of the project. The findings will continue to advancing community-centered approaches that enhance Black women’s access to sexual health care.

Comparing Different Methods for Assessing Substance Use Post-Release Among Justice-Involved Youth

Type: Graduate
Author(s): Brianna Pitz Psychology Danica Knight Psychology Kevin Knight Psychology Yang Yang Psychology
Advisor(s): Yang Yang Psychology
Location: Third Floor, Table 5, Position 2, 1:45-3:45

Substance use is a pervasive issue in adolescents, and justice-involved youth are at a heightened risk of SU compared to the general youth population. Monitoring individual SU trajectory such as initiation, escalation of use, progression, and reductions is important for identifying key prevention and intervention opportunities. There are tools to assess SU in youth populations, but little research has been conducted to compare these assessments in terms of how they accommodate sporadicity of SU within various time frames. This study compared two self-reported measures for post-release SU—Timeline Follow-Back (TLFB) and Substance Use Involvement Scale (SUIS)—within youth who were recently released from secure residential facilities. The aims of this study are to examine the differences between TLFB and SUIS in (1) alcohol and cannabis use (yes/no), (2) the cumulative number of days of alcohol and cannabis use, and (3) the average daily use frequency for youth who have initiated alcohol and cannabis use post-release. This study used a subsample of 89 youth who reported post-release SU. Results revealed that (1) SUIS reported significantly greater number of youth that indicated alcohol and cannabis use (ps ≤ .001) than TLFB, (2) SUIS and TLFB did not differ in cumulative number of days of cannabis use (p = .40), but SUIS recorded a significantly greater number of days of alcohol use than TLFB (p ≤ .001), and (3) SUIS reported significantly greater average frequency of use per day for both cannabis and alcohol use (ps ≤ .001) compared to TLFB. TLFB provided more in-depth results for individual participants’ SU patterns including date of initiation post-release and day-by-day frequencies of use compared to SUIS. Despite TLFB’s advantages, additional strategies are needed to optimize the intensive process of data capturing and to support the external validity for capturing long-term SU. SUIS adequately captured data for sporadic SU without an overwhelming amount of data that worked well for comparing broad patterns of SU. These findings collectively show the importance of TLFB and SUIS measures in addressing different research goals.

Bleeding Votes: The power of period imagery in politics.

Type: Graduate
Author(s): Bao Han Tran Psychology Cathy Cox Psychology
Advisor(s): Cathy Cox Psychology
Location: Basement, Table 13, Position 1, 1:45-3:45

Menstruation is stigmatized in many areas of society, often leading to distancing behavior and increased objectification of women. This is commonly reflected in the widespread use of euphemisms, or metaphors, for menstruation. According to conceptual metaphor theory, a society is shaped by the metaphors it adopts. When menstruation metaphors are used in a political context, it raises questions about whether their harmful connotations affect political appeal and broader societal implications. This study explores the power of menstrual metaphors in political attack ads, specifically focussing on the “Tampon Tim” campaign. Participants were randomly assigned to view one of three political ads (i.e., metaphor, non-metaphor, and neutral) and answer questions about ad appeal and individual differences. Results support our hypothesis that menstruation metaphors influence political opinions.

Increasing PrEP Access for Black Women: The Role of Beauty Professionals in HIV Prevention Education

Type: Graduate
Author(s): Stephanie Villaire Psychology Sakina Ghafoor Psychology Savannah Hastings Psychology Quinceola Reid Psychology
Advisor(s): Kevin Knight Psychology Pamela Carey Psychology Randi Proffittt Psychology
Location: Basement, Table 6, Position 2, 11:30-1:30

Among women in Texas, Black women account for 56% of new HIV infections. However, Black individuals receive only 14% of prescriptions for PrEP, a medication that prevents HIV transmission. In an effort to increase PrEP uptake among Black women, the Beauty Shop Study engages beauty professionals as trusted community members, equipping them to provide sexual health education to their clients. Clients are then connected with the TCU Mobile Health Unit for service delivery and/or referral coordination. In the initial phase, the study collected Beauty Shop Study needs assessment data from 32 beauty professionals in North Texas, exploring their experiences discussing sexual health and related topics with their clients. The current study will present these findings to highlight community readiness and the importance of the Beauty Shop Study.

Native Grassland Stewardship: An Archetype for Sustainable Management

Type: Graduate
Author(s): Riley O'Connor Ranch Management Brooke Best Ranch Management Kelton Eason Ranch Management Jeffrey Geider Ranch Management Ashley Titus Ranch Management
Advisor(s): Jeffrey Geider Ranch Management
Location: Third Floor, Table 10, Position 2, 11:30-1:30

Native Grassland Stewardship: An Archetype for Sustainable Management

Fort Worth, Texas, encompasses two significant tallgrass prairie ecosystems: the Blackland Prairie and the less-studied Fort Worth Prairie. Currently, less than 1% of these prairies remain due to escalating urban expansion, unsustainable agricultural practices, and the growth of the energy sector (Robison et al., 1995). With over 93% of Texas land under private ownership, effective conservation strategies must inclusively engage all stakeholders, notably land managers (Texas Parks and Wildlife, 2025). This study aims to develop a comprehensive management plan for the native prairie ecosystem located within the Botanical Research Institute of Texas at the Fort Worth Botanic Garden. The proposed plan is designed to act as an archetype for regeneratively managed prairies and ranches.
Field methodologies encompassed a detailed vegetation survey, forage-clipping analyses, and identification of dominant species. From an ecological perspective, this research emphasizes the critical role of adaptive management in restoring native ecosystems, fostering responsible land stewardship, and promoting public engagement in grassland conservation. The findings aim to contribute practical insights for landowners, conservationists, and policymakers dedicated to preserving and sustainably managing tallgrass prairies in North Texas.

Keywords: Prairie Conversation, Adaptive Management, Sustainable Grazing, Ranch Management

References
Robison, R., White, D. B., & Meyer, M. H. (1995). Plants in Prairie Communities. St. Paul, MN: University of Minnesota. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/93930.
Texas Parks and Wildlife. (2025). Private Landowners and Listed Species. https://tpwd.texas.gov/wildlife/wildlife-diversity/nongame/listed-species/private-landowners-and-listed-species/

Visualizing the Structural Effects of Proline Variants on the BRCA1-PALB2 Binding Interface

Type: Graduate
Author(s): Chrissy Baker Biology Sergei Dzyuba Chemistry & Biochemistry Mikaela Stewart Biology
Advisor(s): Mikaela Stewart Biology
Location: Basement, Table 11, Position 1, 11:30-1:30

Both Breast Cancer Gene 1 (BRCA1) and Partner and Localizer of BRCA 2 (PALB2) interact through their coiled-coil domains and are critical for proper functioning of DNA repair through homologous recombination. Individuals who carry pathogenic variants in either protein have an increased risk of developing breast cancer. Multiple variations of unknown significance (VUS) have been documented within the coiled-coil region of each protein, meaning a person carries a variation in either BRCA1 or PALB2 but there is not enough data to know the clinical significance of those variants. In this study, we analyzed the structural effects of five proline VUS within the binding region of BRCA1 and PALB2, three variants that have been discovered in patients and two variants that have not yet been discovered in patients. We used a known benign valine variant and a known pathogenic proline variant as our negative and positive controls, respectively. Because proline variants are known to disrupt protein structure, we hypothesize the proline variants will inhibit coiled-coil formation and, in turn, disrupt interaction between BRCA1 and PALB2. Each coiled-coil construct was generated in vitro and its structure analyzed using circular dichroism first individually and then in the presence of its wild-type binding partner. While all proline variants affected the structure of BRCA1, they had different degrees of impact depending on where they are located in the coiled-coil. This suggests that proline variants impact the ability of BRCA1 to form a coiled-coil in the presence of PALB2 and may be pathogenic. Notably, however, the BRCA1 proline variants seem to cause different structural changes from the pathogenic PALB2 proline variant. This prompts further research to determine the structural effects on the residue level and to correlate structural changes with functional changes.